RECETOX Events 28 June - 2 July 2021

OECD Guidelines for the testing of chemicals

On 14 June OECD member countries and countries adhering to the Mutual Acceptance of Data system have adopted 12 documents comprising new, updated and corrected Guidelines for the testing of chemicals.

New:

• Test Guideline No. 249: Fish Cell Line Acute Toxicity: The RTgill-W1 cell line assay
• Test Guideline No. 250: EASZY assay: Detection of Endocrine Active Substances, acting through estrogen receptors, using transgenic tg(cyp19a1b:GFP) Zebrafish embrYos
• Guideline No.497: Defined Approaches for Skin Sensitisation
• Test Guideline No. 498: In vitro Phototoxicity: Reconstructed Human Epidermis Phototoxicity test method
  

Updated:

• Test Guideline No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Methods
• Test Guideline No. 442C: Key Event-Based Test Guideline for in chemico skin sensitisation assays addressing the Adverse Outcome Pathway Key Event on Covalent Binding to Proteins
• Test Guideline No. 494: Vitrigel®-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage
• Test Guideline No. 509: Crop Field Trial
  
  

Corrected:

• Test Guideline No. 208 (French version only): Essai sur plante terrestre : essai d'émergence de plantules et de croissance de plantules
• Test Guideline No. 405: In Vivo Eye Irritation/Serious Eye Damage
• Test Guideline No. 406: Skin Sensitisation Guinea Pig Maximisation Test and Buehler Test
• Test Guideline No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists
  
  

All of these Guidelines were elaborated with the assistance of lead countries and/or expert groups providing input (i.e. experimental/validation work, (statistical) analysis, data collection and curation). Draft documents have been reviewed multiple times by country experts to improve the final product. All of these Guidelines enable the production of results that are covered by the Mutual Acceptance of Data system, when used in laboratories that are GLP certified.

A number of supporting documents (validation reports, peer-review reports, guidance documents) will be published in Q3 2021 in the OECD Series on Testing and Assessment.

• HERA webinar on chemicals management for healthy future,  30 June 2021, 1:30 pm
  
  
• Webinar - Nová vyhláška o podrobnostech nakládání s odpady, 30 June 2021, 9:00 am
  
  
• Webinar organized by Maria Arena, Member of the European Parliament on current opportunities and challenges around endocrine disrupters identification and regulation, 1 July 2021, 2:00 pm
  
  
• Brněnské dny bez úrazu, 11 August 2021, 3:00 pm
  
  
• Festival vědy,  3 - 4 September 2021
  
  
• 4th HERA online webinar "Climate Change, Cities and Health", 17 September 2021
  
  
• Researchers´ Night 2021, 24 September 2021
  
  
• The International Congress of Toxicology (ICT 2022), 18 - 22 September 2022