Research areas

Our research group deals with numerous research activities, which are divided in three main areas:

 

Occupational exposure of Firefighters

Key words: cohort study, PFAS, other pollutants v.s. biomarkers of effect and biomarkers of exposure; Human DNA damage in vivo; DNA methylation as an epigenetic biomarker; supplementation, fitness, other parameters

Pesticide mixtures

Key words: cohort study, suspect screening analysis, biomarkers of effect (oxidative stress, DNA damages), assessment of indoor DUST 

Genotoxicity

Key words: In vitro Genotoxicity potential assessment (human stem cells, procaryotic cell line, QIVIVE approach) – Benztriazoles and Probabilistic Human Health Risk Assessment  

URBAN Exposome

Key words:Urban populations, urbanization, exposure, pollution, noise, adverse health effects

Other research topics

  • Retrospective exposure assessment – the use of biomonitoring studies for retrospective reconstruction of exposure by PBPK modeling (biomonitoring of breast milk in the human population in CR) and probabilistic human health risk assessment.

  • Indoor air sampling & inhalation risk assessment – exposure assessment of new POPs. Probabilistic risk assessment in human population (MonteCarlo simulation – Risk assessment) 

  • The Experimental ex-vivo approach: on fully automated Franz cell system with human skin (Dermatotoxicokinetic parameters). 

  • Targeted studies for refinement of exposure of selected chemical substances – SkinRISK project (Kinetics of the percutaneous penetration of optical isomers in sunscreens, brominated flame retardants and polar pesticides in dermal exposure) and use of these parameters for toxicokinetic (PBTK) models. 

  • Toxicological characterization of UV filters – sunscreens – its fotodegradation products and optical izomers. 

  • The development of new methods for external exposure assessment – ambient air – SENSORS – SMART CITIES. 

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