ESR 1: Yang Wang
Country of origin: China
Host institution: Aarhus University
Yang obtained his Master of Science degree in biochemistry and molecular biology from Shantou University, Shantou, China. His master's thesis was focused on analysis of physiological and molecular response in critical pathways to abiotic stressors. After his graduation, he worked as a research assistant independently in metabolic, proteomic and transcriptomic experiments and analysis in genetics lab of Shantou University where he developed his hands-on abilities and solid theoretical groundwork.
Following his research in the academic field, Yang worked as a project manager in in vitro diagnostic industry. He was mainly responsible for several clinical projects of novel diagnostic technologies including blood circulating tumor cells test, multiple mRNA in situ analysis and HPV DNA hybridization, in order to promote new technologies in disease diagnosis and improve sensitivity and specificity of molecular tools.
Yang was employed as a PhD fellow in the project of PRORISK in Martin Holmstrup’s team since September 2020. His research focuses on mechanisms of exposure to natural stressors and contaminants on soil invertebrates. What he is concentrating on is to study the physiological/molecular mechanisms of invertebrates to multiple stressors (natural and man-made). Moreover, natural stressors can affect the chemicals’ toxicokinetics. By studying the effects of multiple stressors, it is possible to reveal potential synergistic, additive and antagonistic interactions. Thus, he will contribute to investigating detoxification mechanisms involved in toxicokinetics/toxicodynamics.
|Project title:||Underlying physiological mechanisms of interactions between effects of exposure to contaminants and natural stressors|
|Objectives:||Identify and analyse interplay between physiological/molecular mechanisms involved in toxicokinetics/toxicodynamics under influence of natural stressors.
Develop RNA interference (RNAi) methods that will help understand the transcriptional molecular responses to contaminant exposure, and to identify the most important molecular responses in detoxification and defence mechanisms.
|Expected results:||Understanding importance of relevant natural stressors in detoxifying contaminants and defensive stress response mechanisms.
Using RNAi (with ESR4), novel understanding and identification of important detoxification mechanisms, facilitating selection of relevant transcriptional biomarkers for further refinement/development of toxicity screening procedures used in chemical RA.
|Planned secondments:||RIWA, M18, 2 months, Hands-on introduction to risk assessment
UdG, M27, 2 months, investigate physiological effects of non-chemical stressors
|Work packages:||2 - Exposure and chemical-biological interactions
3 - Linking molecular responses to effects at higher biological levels using adverse outcome pathways (AOPs)
|Supervisor:||Prof. Dr. Martin Holmstrup, AU|
||Dr. Gerard Stroomberg, RIWA
Dr. Stine Slotsbo, AU
|Host institution and enrolment:||Aarhus University|