The PRORISK project contains 9 Work Packages (WPs) that create an overlapping system for 15 involved ESR projects covering together the entire focus range from exposure to effects on ecosystem functioning and their potential socio-economic consequences. The research in WP2 to WP5 is coordinated (WP7) with a comprehensive set of training (WP1) and dissemination and outreach activities (WP6).
WP1 is dedicated to training of highly employable young researchers and risk assessors that will strengthen and support organizations in sectors such as industry, SMEs, regulation, governments, NGOs and academia.
Within PRORISK a specialized training (including ATCs, co-supervision, secondments, masterclasses) is organized and ESR progress will be continuously monitored.
WP2 will develop organ and/or tissue-specific molecular methods as indicators of internal exposure and chemical-biological interactions and investigate how natural stressors influence these endpoints. The results will complement the work of WPs 3-4 in order to map the complete AOP of single and combined effects of chemical and non-chemical stressors, and how this leads to altered ecosystems services.
WP3 - Linking molecular responses to effects at higher biological levels using adverse outcome pathways (AOPs) (Lead beneficiary: VUA)
WP3 will develop conceptual AOPs and qAOPs, advanced bioassay tools and extrapolation methodologies. WP3 is directly linked to WP2 (Exposure and chemical-biological interactions) and WP4 (extrapolating mechanistic information to ecosystem services).
In WP4 modelling and experimental approaches will be combined to develop ecological productions functions based on AOPs. Information from mesocosms and models will be integrated to develop an approach addressing ecosystem service interactions.
WP5 will develop novel approaches for the risk assessment of chemicals, incorporating advanced understanding of chemical-biological interactions (WP2), AOPs/qAOPs and individual-population relationships (WP3), and ecosystem services (WP4). In addition, WP5 will develop an approach using the ecotoxicity damage modelling and accounting for socio-economic consequences.
WP6 aims to (1) disseminate the relevant knowledge generated by PRORISK to specialized research fora and to policy makers, regulators and stakeholders; (2) disseminate structure of novel comprehensive forum for interdisciplinary research and research-training; (3) provide training and perform outreach activities addressed to non-specialized audiences.
WP7 concerns coordination and overall management of PRORISK to smoothly and coherently run the work in all WPs, and in line with the implementation section, communication within the consortium as well as with the European Commission.
WP8 is dedicated to management of research data within PRORISK and in compliance with the open access policy.
The WP9 objective is to ensure compliance with the ethics requirements set out in this Work Package.