ESR 4:


Country of origin:

Host institution: Masaryk University

Contact:

Project

Project title: Linking metabolic and reproduction disruptions after exposures to novel flame retardants
Objectives:

To characterize MoAs and ecotoxicological effects of novel classes of flame retardants (FRs) in zebrafish.
To establish AOP network linking metabolic-endocrine-reproduction disruption caused by FRs.

Expected results:

MIEs, KEs and AOs related to toxicity of novel FRs including toxicogenomics responses.
In vitro assay(s) for high through-put screening (HTS) or ecotoxicant effects.
Characterization of a (network of) AOPs linking metabolic-endocrine-reproduction outcomes relevant for FRs.

Place: Brno, Czech Republic
Planned secondments:
RIWA, M20, 2 months, FRs and water quality assessment
NIVA, M24, 2 months, toxicogenomic studies
Work packages: 3 - Linking molecular responses to effects at higher biological levels using adverse outcome pathways (AOPs)
4 - Predicting effects on ecosystem services through AOPs
Supervisor: Ludek Blaha, MU
Host institution and enrolment: Masaryk University