Dr. Klára Komprdová
PI at "Pharmacokinetic modeling" research group
Klára Komprdová is a co-leader of the " Pharmacokinetic Modelling " research group. She received an M.Sc. degree in Mathematical Biology and a PhD degree in Environmental Chemistry at RECETOX, Masaryk University.
She is a biostatistician with the primary focus on the statistical analysis of human biomonitoring data and development of toxicokinetic models. Her main research interests include evaluating human exposure, mainly the potential effect of pollutants on (neuro)development of children, using toxicokinetic models. Modelling also includes simulation of pollutants in tissues under different conditions, calculations of intake in time during exposure and identification the primary exposure sources. Other areas of interest are developing a QSAR (Quantitative Structure-Activity Relationships) models to predict the toxic potential of pollutants, based on their structural and physico-chemical properties.
She is an author of 25 scientific publications with over 380 citations and has an H-index of 13.
She is a regular supervisor of bachelor and master students and teaches courses: Advanced non-parametric methods, Modelling and Interpretation of Environmental, Modelling and Interpretation of Environmental Data – Practicals.
Professors
Assistant Professors
Publications
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The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study
SCIENCE OF THE TOTAL ENVIRONMENT, year: 2023, volume: 881, edition: July 2023, DOI
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Time-trends in human urinary concentrations of phthalates and substitutes DEHT and DINCH in Asian and North American countries (2009-2019)
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, year: 2023, volume: 33, edition: 2, DOI
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Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers
Science of the Total Environment, year: 2022, volume: 830, edition: July 2022, DOI
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Personal care product use and lifestyle affect phthalate and DINCH metabolite levels in teenagers and young adults
Environmental Research, year: 2022, volume: 213, edition: October 2022, DOI
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Dynamics of PCB exposure in the past 50 years and recent high concentrations in human breast milk: Analysis of influencing factors using a physiologically based pharmacokinetic model
Science of the Total Environment, year: 2019, volume: 690, edition: NOV 2019, DOI
Projects
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Výzkum studentů v oblastech chemie životního prostředí, hodnocení rizik a vztahů ke zdraví, v roce 2023 (MUNI/A/1117/2022)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2023 — 12/2023Investor: Masaryk University / Specific research - support for student projects -
CETOCOEN Plus (CZ.02.1.01/0.0/0.0/15_003/0000469)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 11/2015 — 6/2023Investor: Ministry of Education, Youth and Sports of the CR / Operational Programme Research, Development and Education -
Výzkum studentů v oblastech chemie životního prostředí, hodnocení rizik a vztahů ke zdraví, v roce 2022 (MUNI/A/1364/2021)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2022 — 12/2022Investor: Masaryk University / Specific research - support for student projects -
European Human Biomonitoring Initiative (733032)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2017 — 6/2022Investor: European Union / Horizon 2020 -
Výzkum studentů v oblastech chemie životního prostředí, hodnocení rizik a vztahů ke zdraví, v roce 2021 (MUNI/A/1566/2020)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2021 — 12/2021Investor: Masaryk University / Specific research - support for student projects