doc. Ing. Vlad Popovici, PhD
Integrative bioinformatics and biostatistics
| phone: | +420 549 49 6848 |
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Assoc. prof. Vlad Popovici
PI at "Integrative bioinformatics and biostatistics" research group
Vlad Popovici is Associate Professor with RECETOX at Masaryk University and principal investigator in the Integrative Bioinformatics and Biostatistics group. He graduated with Engineering degree in computer science from Technical University of Cluj-Napoca, Romania, and obtained his doctoral degree in Electrical Engineering from Ecole Polythecnique Federal de Lausanne, Switzerland.
Dr. Popovici has extensive experience in bioinformatics for biomarker discovery and his research focuses on developing new methods for joint analysis of OMICS and imaging data, by combining computational pathology with more traditional bioinformatics approaches. The results are mainly applied to the identification of novel predictors in precision oncology, most notably for colon and breast cancers.
Dr. Popovici authored or co-authored more than 66 papers that were cited >2,500 times for an h-index of 17. He was involved in a number of European and national projects, being PI in an EU-FP7 project, 2 grants of Ministry of Health, one grant of the Czech Grant Agency and he is an Marie-Curie/SoMoPro alumnus.
Publications
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A Phase Ia/b study of MEK1/2 inhibitor binimetinib with MET inhibitor crizotinib in patients with RAS mutant advanced colorectal cancer (MErCuRIC)
BMC Cancer, year: 2025, volume: 25, edition: 1, DOI
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A quantitative tumor-wide analysis of morphological heterogeneity of colorectal adenocarcinoma
JOURNAL OF PATHOLOGY CLINICAL RESEARCH, year: 2025, volume: 11, edition: 4, DOI
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Impact of the ONCOBIOME network in cancer microbiome research
Nature Medicine, year: 2025, volume: 31, edition: 4, DOI
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Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer
Nature Medicine, year: 2025, volume: 31, edition: 7, DOI
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Search for Mutations Connected With Non-Response to Anti-EGFR Therapy in mCRC in the Morphologically Defined Regions of Primary Tumours
Cancer Medicine, year: 2025, volume: 14, edition: 9, DOI
Projects
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Saving lives through research in early cancer detection and prevention: Molecular, genomic and societal factors (CZ.02.01.01/00/22_008/0004644)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2024 — 6/2028Investor: Ministry of Education, Youth and Sports of the CR / OP JAK -
Discovering the causes of three poorly understood cancers in Europe (101096888)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2023 — 12/2027Investor: European Union / Horizon Europe -
CETOCOEN Excellence (857560)
MU Researcher: prof. RNDr. Jana Klánová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2020 — 12/2027Investor: European Union / Horizon 2020 -
Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response (825410)
MU Researcher: Mgr. Eva Budinská, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2019 — 6/2025Investor: European Union / Horizon 2020 -
Clinical implications of intra-tumour heterogeneity in colon cancer (NV19-03-00298)
MU Researcher: doc. Ing. Vlad Popovici, PhD MU Faculty or unit: Faculty of Science Project Period: 5/2019 — 12/2023Investor: Ministry of Health of the CR / Ministry of Health Research Programme 2015 - 2022