Prof. Julie Dobrovolná
(previously Julie Bienertová-Vašků)
PI of "Environmental physiology" research programme
Julie Dobrovolná (previously Bienertová-Vašků) completed her Ph.D. in Pathophysiology in 2009 at Masaryk university and has been Associate Professor of Physiology and Pathophysiology at the Masaryk university since 2013. In 2003 and 2008, she took the visiting researcher position in INSERM Unit U781, Necker Hospital, Paris and where she collaborated on the project supervised by Dr. Agnes Rötig and Prof. A. Munnich. Since then, she has developed multiple international collaborations with excellent institutions (Dr. D. Fairweather at Mayo Clinic, US; prof. T. Lotti at University of Studies Guglielmo Marconi, IT, dr. P. Joshi at University Edinburgh, UK, the team of prof. Vandesompele at Center of Medical Genetics at Ghent University, Belgium and others).
Her expertise lies mainly in the assessment of environmental influences on human health outcomes, with special emphasis on changes in adipokine expression under different environmental conditions and on their involvement in molecular pathophysiology of obesity. Her current programme is mainly focused on identification of associations between environmental exposure and alterations in adipose tissue in humans. She has additional interest in development of novel methodology for measurement of stress and in re-definition of general concepts of stress.
She has published more 74 WOS articles, has >780 citations in WOS, h-index 15. Prof. Dobrovolná served as editor to and co-authored several monographies and monography chapters focused mainly on body fat and its role in pathophysiology of complex diseases. Prof. Dobrovolná has also a EPO/Japanese patent: EP2888275 A1- B-cell activating factor for increasing mucosal immunity of infants as well as sucklings and a preparation containing this factor that is based solely on the findings of her team.
Prof. Dobrovolná received numerous prizes: 2014 - Masaryk University Rector’s Award for the Young Scientist; 2009 – 2nd place in the Prix de Pharmacie national competition held under the auspices of the French Embassy of the Czech Republic and Sanofi-Aventis company; 2003 – 1st place in the Prix de Medecine national competition held under the auspices of the French Embassy of the Czech Republic; 2003 – Masaryk University Rector’s Award. Also, she mentored and supervised multiple future awardees of these awards (Martin Horak, Ivo Necesanek, Jan Novak) and for years has been participating within the jury of these awards.
She teaches numerous courses both at the Faculty of Medicine and Faculty of Sciences MU, including Pathological Physiology, Genetics, Human Molecular Biology, and Obesitology. She is also a member of the doctoral board in the field of Pathological Physiology. She has successfully supervised the total of 14 MSc/BSc students who successfully defended their theses in Biochemistry, Nutritional Therapy and Molecular Biology and currently supervises the total of 8 Ph.D. students with one successfully having graduated already.
Prof. Dobrovolná is also participating in numerous PR activities of the Masaryk University and organization thereof: annual organization of the Scientists’ Night and annual round of Children’s University (MjUNI) and is a recognized speaker (TEDx talk, ScienceCafé, ScienceSlam activities, promotion of autism awareness). She is also a guarantor of the “Healthy people” part of the strategy Brno2050 in the framework of smart-cities project in her residental city of Brno.
Publications
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Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease
Metabolism: Clinical and Experimental, year: 2022, volume: 126, edition: January 2022, DOI
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Proteomic Signatures of Human Visceral and Subcutaneous Adipocytes
Journal of Clinical Endocrinology and Metabolism, year: 2022, DOI
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Birth weight rather than birth length is associated with childhood behavioural problems in a Czech ELSPAC cohort
Plos one, year: 2021, volume: 16, edition: 7, DOI
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Dietary pattern longitudinality during 8 years in children: results from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ)
Public Health Nutrition, year: 2021, volume: 24, edition: 9, DOI
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Homeostatic model of human thermoregulation with bi-stability
Nature Scientific Reports, year: 2021, volume: 11, edition: 1, DOI
Projects
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Klinické a proteomické biomarkery predikujcí reverzní remodelování levé komory u pacientů s nově zjištěnou dilatační kardiomyopatií (NU22-02-00418)
MU Researcher: MUDr. Jan Novák, Ph.D. MU Faculty or unit: Faculty of Medicine Project Period: 5/2022 — 12/2025Investor: Ministry of Health of the CR / Ministry of Health Research Programme 2020 - 2026 -
Neurobiological and psychological markers of war-related stress in civilian population: a two-generation study of Balkan war survivors (NU22-04-00661)
MU Researcher: prof. MUDr. Ivan Rektor, CSc. MU Faculty or unit: Central European Institute of Technology Project Period: 5/2022 — 12/2025Investor: Ministry of Health of the CR / Ministry of Health Research Programme 2020 - 2026 -
Comprehensive optimization of the service of members of the 601st Special Forces Group of the Czech Armed Forces (OYMASUN202201)
MU Researcher: doc. PhDr. Bc. Zdenko Reguli, Ph.D. MU Faculty or unit: Faculty of Sports Studies Project Period: 1/2022 — 12/2024Investor: Ministry of Defence of the CR / Other grant projects -
Stresová rezilience a vyrovnávání se s fyzickým a verbálním útokem (GA22-36623S)
MU Researcher: prof. MUDr. Julie Dobrovolná, Ph.D. MU Faculty or unit: Faculty of Sports Studies Project Period: 1/2022 — 12/2024Investor: Czech Science Foundation / Standard Projects -
Stress of Citizens and Entropy in Urban Setting (MUNI/G/1249/2021)
MU Researcher: prof. MUDr. Julie Dobrovolná, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 4/2022 — 12/2024Investor: Masaryk University / Grant Agency of Masaryk University
More information
Supervised theses
Field of study: Computational biology, bioinformatics and modelling
Topics of doctoral theses (supervisor)
- Trajektorie akutního i chronického stresu u člověka se specifickým zaměřením na izolační experimenty (kosmický výzkum + izolované geografické oblasti) – ongoing study
Field of study: Environmental chemistry and toxicology
Topics of doctoral theses (supervisor)
- Urban stress as a physiological phenomenon – ongoing study
Field of study: Molecular and Cell Biology and Genetics
Topics of doctoral theses (supervisor)
- Evolutionary mechanisms affecting the fixation of specific rates of aging in sexually reproducing organisms – graduate 2021
- Clarification of FSTL1 protein function in mitochondrial energy metabolism in vitro and in heart failure – graduate 2019
Field of study: Pathological Physiology
Topics of doctoral theses (supervisor)
- Fyziologické markery stresu (variabilita tepové frekvence, eye-tracking a kožní vodivost) v predikci stresu v éře chytrých (smart) nositelných prostředků – ongoing study
- Asociace vybraných proteomických markerů s tělesným složením – ongoing study
- Analysis of objects in the cardiovascular ultrasound sequences and their implementation in the new diagnostic procedures – graduate 2022
- The pathophysiological role of nutritional determinants of growth in Central European children and adolescents – graduate 2021
- Entropy in relation to the initiation/course of a stress response and its connection with the transgenerational transmission of information – graduate 2021
Field of study: Pathological Physiology
Topics of doctoral theses (supervisor)
- Prediktivní faktory reoperací u pacientů se subdurálním hematomem – ongoing study
Field of study: Physiology and Pathological Physiology
Topics of doctoral theses (supervisor)
- The role of omentin-1 in pathophysiology of complex diseases – graduate 2017
- Molecular biological methods for studying cells redox state in prostate carcinoma – graduate 2014
Teaching
Courses taught
Academic year 2021–2022
Spring 2022 at Faculty of Medicine
- Doctoral thesis preparation
- Genetics
- Obesitology II - lecture
- Obesitology II - practice
- Pathological Physiology II - lecture (aZLPF0622p, ZLPF0622p)
- Pathophysiology II - lecture (aVLPF0622p, VLPF0622p)
- Research preparation II
- Research preparation VIII - practice
- Research preparation X - practice
- Vědecká příprava IV
- Vědecká příprava VI
Autumn 2021 at Faculty of Medicine
- Doctoral thesis preparation
- Introduction to research XI: thesis preparation - lecture
- Obesitology I - exercise
- Obesitology I - lecture
- Pathohysiology I - lecture
- Pathological Physiology I - lecture
- Patholphysiology I - lecture
- Pathophysiology I - lecture
- Research training III
- Research training IX
- Research training V
- Research training VII
- Research training XI