Consortium in brief

To establish the Centre of Excellence in Environmental Health Sciences the Masaryk University will be supported by leading European research institutions - University College London (UCL), Swiss Federal Institute of Technology in Zurich (ETH), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-ERIC), and International Clinical Research Centre (ICRC) at St. Anne’s Hospital. 

Masaryk University, which is the second biggest university in the Czech Republic, is the coordinator of the project. The RECETOX Centre, established in 1983 at the Faculty of Science, is responsible for the project implementation at the the Masaryk University. RECETOX is engaged in research and education in the field of management of environmental and health risks related to chemicals around us. RECETOX Centre is the entity around which the European Centre of Excellence is being developed. 


UCL is London’s leading multidisciplinary university, and is currently ranked as the 5th best university in Europe and the 15th worldwide and it has one of Europe’s largest and most productive centres for biomedical science. UCL brings the multidisciplinary expertise covering epidemiology, public heath, psychobiology, statistics and sociology, genetics, epigenetics and omics methods, with a strong emphasis on longitudinal studies, life-course determinants of health and environmental predictors of chronic conditions.


ETH Zurich is leading technical university, which is ranked 6th in the world and 2nd in Europe in 2019 and by subject is ranked 3rd in the world and 1st in Europe for engineering and technology. ETH is the strategic partner for development of the highly competitive research field of microfluidics and nanoscale science with a great application potential.


BBMRI-ERIC is a pan- European distributed RI of biobanks. Its role is to support establishment of standardized procedures in on-going and new regional studies, and to facilitate the access to available resources in compliance with the FAIR-Health principles extended with principles specific to medical research related to reproducibility, quality of samples and data, and privacy protection.


International Clinical Research Centre of the St.Anne's University Hospital is the project partner combining fundamental and translational research with clinical medicine. This will provide us with the possibility to draw ICRC’s knowledge and expertise in the management and operations of the research Centre responsible for running population cohorts and clinical studies, which includes significant efforts in building reliable systems and policies, including the ethical issues.


 

 

Role of partners

Masaryk University

Masaryk University is a public education and research organisation, founded in 1919 as the second Czech university, in Brno, South Moravian Region. It comprises of nine faculties and two university institutes with over 200 departments, institutes and clinics, more than 37,000 students and 4,500 employees, making it the second largest university in the Czech Republic. 

RECETOX

The Centre, which is responsible for the project's implementation and is also its primary beneficiary, is an independent department of Masaryk University’s Faculty of Science in Brno, Czech Republic, celebrating more than 35 years of academic and research excellence in the fields of environmental and health. Although it initially focused on the interactions among chemicals, environments, and biological systems, and their consequences on local, regional, and global levels, the Centre’s current, and long-term strategic vision is to become an international center of excellence, supporting research and education focused on unravelling the role of environmental factors in human health, aging, and wellbeing, developing innovative approaches to environmental and health protection, and tools for prevention, diagnostics, and intervention.

RECETOX is currently the faculty’s most successful institute in terms of number of implemented European framework projects (now c. 17 H2020 projects), and its research infrastructure (RI) is included in the Czech National Roadmap of Large Infrastructures for Research, Development, and Innovation. RECETOX is currently conducting two major longitudinal cohort studies, operates accredited trace analytical laboratories, environmental databases, and information systems. RECETOX also serves as the Regional Centre of the Stockholm Convention for Capacity Building and Technology Transfer in Central and Eastern Europe and the National Centre for Toxic Compounds of the Czech Republic.

Over the last decade, RECETOX has earned an international reputation in the environmental sciences, especially in the fields of environmental analytical chemistry, toxicology and modelling.

Key people

prof. RNDr. Jana Klánová, Ph.D.

RECETOX Director & Project coordinator

E‑mail:

prof. RNDr. Luděk Bláha, Ph.D.

Vice-dean of Faculty of Science, Research programme leader at RECETOX

E‑mail:

prof. RNDr. Jakub Hofman, Ph.D.

WP4 Leader, Research group leader at RECETOX

E‑mail:

Mgr. Lenka Helclová

WP5 Leader, HR manager at RECETOX

E‑mail:

Ing. Barbora Prokešová

WP6 Leader, Head of Grant Office at RECETOX

E‑mail:

 Inactive employment status

Mgr. Vojtěch Přibyla, MBA

WP7 Leader, CEO at RECETOX

E‑mail:

Ing. Kateřina Šebková, Ph.D., M.A.

WP8 Leader, Dissemination manager, Director of the National and Regional Centre

E‑mail:

Ing. Šárka Palátová, Ph.D.

Administrative and Financial Manager

E‑mail:

MVDr. Shachar D'vir

Project Management Team member

E‑mail:

Ing. Jan Ostřížek, Ph.D.

Project Management Team member

E‑mail:

University College London

UCL is London’s leading multidisciplinary university, and is consistently ranked among top ten in the world by the QS World University Rankings. Its publications attract more citations from fellow researchers than any other university outside North America. UCL excellence extends across all academic disciplines, and it has one of Europe’s largest and most productive centres for biomedical science. Four UCL academic units will participate in this project.

UCL in the TEAMING

UCL will bring multidisciplinary expertise covering epidemiology, public heath, psychobiology, statistics and sociology, genetics, epigenetics and omics methods, with a strong emphasis on longitudinal studies, life-course determinants of health and environmental predictors of chronic conditions. UCL will contribute by providing access the phenotype and genotype data and biological  samples in the HAPIEE cohorts, by providing expertise in standardising and harmonising protocols of longitudinal studies, by developing capacity in conducting complex statistical analyses linking environmental exposures with health, training in genetic, epigenetic and other omics methods, and  by direct input in research into environmental and biological exposures and health.

The UCL's administration will assist RECETOX with the development and improvement of specific services, such as grant support or technology transfer. 

Key people

prof. Martin Bobák

Professor, WP2 Leader

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prof. Hynek Pikhart

Professor

E‑mail:

Martin Scott

Head of European Innovation Management

E‑mail:

ETH Zürich

ETH Zürich (Swiss Federal Institute of Technology in Zürich) is an engineering, science, technology, mathematics and management university in the city of Zürich, Switzerland. Founded by the Swiss Federal Government in 1854, ETH Zürich has the stated mission to educate engineers and scientists, serve as a national center of excellence in science and technology and provide a hub for interaction between the scientific community and industry. ETH Zürich is consistently ranked among the top universities in the world, and is currently ranked as 3rd best university in the world in engineering, science and technology.

ETH in the TEAMING

Professor deMello is currently Chairman of the Institute of Chemical and Bioengineering (ICB) at ETH Zürich. The ICB is home to over 250 scientists and engineers working on a broad range of topics including, chemical aspects of energy, heterogeneous catalysis, colloid engineering, biotechnology, bioengineering and microfluidics. The institute is responsible for all undergraduate teaching in Chemical Engineering (Bachelors and Masters level) and trains over 150 PhD students at any one time. Additionally, Professor deMello is an Associated Group Head at the MRC Clinical Sciences Centre at Imperial College London collaborating with a diversity of cell biologists to develop new technologies for stem cell reprogramming. Between 2005 and 2011 Professor deMello was a lead investigator on the £5M EPSRC Single Cell Proteomics initiative at Imperial College London.

In the Teaming project ETH Zürich and RECETOX will together focus on development and application of novel microfluidic platforms for high-throughput imaging cytometry, combinatorial biological assays and high-throughput microfluidic single- cell screening/sorting platforms.

Key people

prof. Andrew deMello

Professor

E‑mail:

Dr. Stavros Stavrakis

Senior Scientist

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prof. Martin Scheringer

Professor

E‑mail:

BBMRI-ERIC

The pan-European Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium (BBMRI-ERIC) improves the accessibility and interoperability of the existing comprehensive collections, either population-based or clinical-oriented, of biological samples from different (sub)populations of Europe. These collections include the attached data on factors such as health status, nutrition, lifestyle, and environmental exposure of the study subjects. Combined with the expertise of the clinicians, pathologists, bio-informaticians, and molecular biologists involved, a globally unmatched, Europe-wide platform for translational medical research is envisaged with the aim to develop personalized medicine and disease prevention for the benefit of European citizens.

BBMRI in the TEAMING

BBMRI will be a crucial partner in the development of new RECETOX biobanking facility and its linking to the European network of the biobanks. It will support harmonization and sharing of data and metadata, establishment and use of existing standards, joint development of relevant new standards enabling linking the environment and health and enable an access to the samples to a variety of users. The BBMRI-ERIC will support harmonization and sharing of biomarker data and metadata for increased reproducibility and fitness for purpose, establishment and use of existing standards, joint development of relevant new standards to facilitate linkages of date on environment exposures with data on health. It will also provide tools to make the collections of the data and biological material findable (using BBMRI-ERIC Directory) and tools to request and negotiate access (using BBMRI- ERIC Negotiator) for a variety of users in line with the FAIR-Health principles.

Key people

Dr. Petr Holub

IT/Data Protection Manager and CIO

E‑mail:

assoc. prof. Dalibor Valík

Head of Czech Node - BBMRI

E‑mail:

Heimo Muller

Researcher, BIBOX

E‑mail:

ICRC - FNUSA 

International Clinical Research Center (ICRC) in Brno, Czech Republic, operates under auspices of St. Anne’s University hospital Brno (FNUSA). ICRC is a new generation science and research center focusing on finding new methods, technologies and medicaments for effective prevention, early diagnostics and individualized treatment of cardiovascular and neurological diseases. Kardiovize Brno 2030 is a health prevention scheme that aims to identify the actual health risks of Brno town citizens, and to minimize these, by 2030, through prevention programs. In the project’s first phase, mapping risk factors for cardiovascular disease is now underway within a randomly selected population of Brno, the participants’ age ranging from 25 to 64 years, while during the second phase, suitable prevention programs will be proposed based on the results obtained, which are to focus on reducing the occurrence of the risk factors identified. ICRC is the most important clinical partner of this project that will collaborate on harmonizing protocols and standard operation procedures in KARDIOVIZE, ELSPAC and TNG studies.

ICRC in the TEAMING

International Clinical Research Centre of the St.Anne's University Hospital will be the project partner combining fundamental and translational research with clinical medicine. As the unique research institute running in the university hospital in local environment, ICRC will deliver the missing expertise in health research. The main representative of the ICRC is Dr. Gorazd B. Stokin, MD who is not only PI of Translational Neuroscience and Aging Research Program but also he is the the Chair of the ICRC so there is assured interaction with relevant expertise.

Key people

prof. Gorazd Stokin

ICRC Chair

E‑mail:

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