Environmental Toxicology

The Environmental Toxicology research programme aims to understand the mechanisms and long-term impacts of acute and chronic exposures to anthropogenic chemicals and natural toxins. The ultimate goal is to predict health and ecosystem risks of complex mixtures present in the environment.

The research extends from molecular and cellular processes to organisms and ecosystems considering the effects of contaminants of emerging concern like endocrine disruptors, pharmaceuticals, currently used pesticides and their nano-formulations or novel flame retardants. In addition, study toxic cyanobacterial blooms in waters, their adverse impacts and remediation options.

Advanced in vitro approaches (molecular and biochemical toxicology) are combined with in vivo (aquatic and terrestrial) laboratory models, and long-term field bioindication studies. We elucidate drivers of toxicity in mixtures and develop and implement advanced effect-based monitoring tools.

Specific research projects support development of the Adverse Outcome Pathway(AOP)-based models and testing strategies, and identification of new biomarkers of effect. The focus is on chronic health outcomes related to developmental-, metabolic-, neurohumoral-, immune- or cancer-related diseases. The experimental toxicogenomics, epigenomics and cellomics research uses advanced biotechnological approaches such as tissue mimicking/three-dimensional tools, high-content analysis (HCA), high-throughput in vitro screenings (HTS) or the use of pluripotent/somatic stem cells.

Principle investigators

RNDr. Iva Sovadinová, Ph.D.

Principle investigator - Stem cells and tissue homeostasis in toxicity

Junior PIs

Mgr. Ondřej Adamovský, Ph.D.

Junior PI - Mechanistic environmental toxicology

Research programs


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